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Responses Submit a Letter to the Editor. Search for related content. In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. In addition, cultured keratinocytes infected with a recombinant adenovirus expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype. Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification. Journal of Lipid Research. You’ll be in good company.

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In support of this notion, we showed that DLK expression was restricted to the granular layer in situ. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLKacts in the epidermis to promote the terminal differentiation of human keratinocytes.

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You’ll be in good company. Responses Submit a Letter to the Editor. 800

This Article First Published on January 28, doi: To whom correspondence may be addressed: Prev Next Table of Contents. View this article with LENS. Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification.

Journal of Lipid Research. In addition, cultured keratinocytes infected with a recombinant dlkk expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype.

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Classifications Mechanisms of Signal Transduction. Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this 800 remain ill defined. In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. Search for related content.

Articles by Germain, L. Submit your work to JBC.

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Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not. Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum.

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